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| Rodrigo A. Cunha |
Associated Professor at the Faculty of Medicine, University of Coimbra
Director of the Dept. Neuropharmacology,Center for Neuroscience of Coimbra
Principal investigator of the research group ‘Purines at CNC’ |
Center for Neuroscience of Coimbra
Institute of Biochemistry, Faculty of Medicine
University of Coimbra
3004-504 Coimbra, Portugal.
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| Phone: +351 239820190 |
| Fax: +351 239822776 |
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| E-mail: cunharod@gmail.com |
| Web: http://cnc.cj.uc.pt/lab_lef/ |
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| Research area |
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| Neuromodulation by adenosine and ATP in the nervous system: adenosine and ATP receptors (expression, binding characteristics, coupling to transducing systems, desensitisation), formation and inactivation of ATP and adenosine, physiological roles (control of neurotransmitter release, of ion channels and of synaptic transmission and plasticity) and role in physio-pathology (aging, hypoxia, epilepsy, diabetic neuropathies, stress, Alzheimer’s and Parkinson’s diseases, neuro-inflammation). |
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| Keywords |
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neuromodulation
adenosine
synapse
plasticity
neurodegeneration
neuroprotection |
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| Key publications |
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108.Shen, H.Y., Coelho, J.E., Ohtsuka, N., Canas, P.M., Day, Y.J., Huang, Q.Y., Rebola, N., Yu, L., Boison, D., Cunha, R.A., Linden, J., Tsien, J.Z., Chen, J.F. (2008) A critical role of the adenosine A2A receptor in extra-striatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum- and forebrain-A2A receptor knockouts. Journal of Neuroscience (in press).
107.Canas, P.M., Duarte, J.M.N., Rodrigues, R.J., Köfalvi, A., Cunha, R.A. (2008) Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Neurobiology of Aging (in press).
106.Rebola, N., Lujan, R., Cunha, R.A., Mulle, C. (2008) Long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses: an essential role for adenosine A2A receptors. Neuron 57, 121-134.
105.Cunha, G.M.A., Canas, P.M., Melo, C.S., Hockemeyer, J., Müller, C.E., Oliveira, C.R., Cunha, R.A. (2008) Adenosine A2A receptor blockade prevents memory dysfunction caused by ß-amyloid peptides but not by scopolamine or MK-801. Experimental Neurology (in press).
104.Yu, L., Shen, H.Y., Coelho, J.E., Araújo, I.M., Huang, Q.Y., Day, Y.J., Rebola, N., Canas, P.M., Rapp, E.K., Ferrara, J., Taylor, D., Müller, C.E., Linden, J., Cunha, R.A., Chen, J.F. (2008) A2A receptors modulate motor activity and MPTP neurotoxicity by distinct cellular mechanisms. Annals of Neurology (in press). |
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