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Arsélio Pato de Carvalho
Investigador, Professor Jubilado
Director
Centro de Neurociências e Biologia Celular (CNC), Universidade de Coimbra
Instituto de Educação e Cidadania (IEC), Mamarrosa
Phone: 919341929
E-mail: carvalho@cnc.uc.pt
Web: http://www.cnbc.pt/
Research area  
Neurociências
Educação e Cidadania
Keywords  
Glutamate
Neurotransmitters
Nitric Oxide
Calpains
Receptors
Antiepileptics
Key publications  
Araújo, I.M., A.F. Ambrósio, A.C. Leal, P.F. Santos, A.P. Carvalho and C.M. Carvalho. Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide in kainate-induced neurotoxicity in hippocampal neurons. J. Neurochem. 85: 791-800, 2003..

Araújo, IM, Ambrósio, A.F, Leal, E.C., Verdasca, M.J, Malva, J.O, Soares-da-Silva, P., Carvalho, A.P. and Carvalho, C.M. Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093. Epilepsia 45: 1498-1505, 2004

Araújo IM, Verdasca MJ, Leal EC, Bahr BA, Ambrósio AF, Carvalho AP, Carvalho CM. Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons.J Neurochem. 91:1322-31, 2004.

Santos AE, Duarte CB, Iizuka M, Barsoumian EL, Ham J, Lopes MC, Carvalho AP, Carvalho AL. Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor. Cell Death Differ 652-60,2006

Araújo IM, Carreira BP, Pereira T, Santos PF, Soulet D, Inácio A, Bahr BA, Carvalho AP, Ambrósio AF, Carvalho CM. Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons. Cell Death Differ. 14:1635-46, 2007
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